Breath based volatile organic compounds in the detection of breast, lung, and colorectal cancers: A systematic review
電子鼻技術用于檢測乳腺癌、肺癌和結直腸癌揮發(fā)性氣體綜述
Ingrid Oakley-Girvan and Sharon Watkins Davis
Cancer Prevention Institute of California, Fremont, CA, USA
Abstract.
BACKGROUND: Detecting volatile organic compounds (VOCs) could provide a rapid, noninvasive, and inexpensive screenin tool for detecting cancer.
背景：檢測揮發(fā)性有機化合物(VOC)可以提供一種快速、無創(chuàng)、廉價的癌癥篩查工具。
OBJECTIVE: In this systematic review, we identified specific exhaled breath VOCs correlated with lung, colorectal, and breast cancer.
目的：在本系統(tǒng)綜述中，我們確定了與肺癌、結直腸癌和乳腺癌相關的特定呼氣VOC。
METHODS:We identified relevant studies published in 2015 and 2016 by searching Pubmed and Web of Science. The protocol for this systematic review was registered in PROSPERO and the PRISMA guidelines were used in reporting. VOCs and performance data were extracted.
方法：通過檢索PubMed和Web of Science對2015年和2016年發(fā)表的相關研究進行鑒定。該系統(tǒng)性審查的方案已在Prospero注冊，報告中使用了Prisma指南。提取揮發(fā)性有機化合物和性能數據。
RESULTS:Three hundred and thirty three records were identified and 43 papers were included in the review, of which 20 were review articles themselves. We identified 17 studies that listed the VOCs with at least a subset of statistics on detection cutoff levels, sensitivity, specificity, area under the receiver operating characteristic curve (AUC), and gradient.
結果：共鑒定出333份病歷，43篇論文，其中20篇為綜述文章。我們確定了17項研究，列出了VOC，其中至少包含檢測截止水平、靈敏度、特異性、傳感器工作特性曲線下面積(AUC)和梯度統(tǒng)計數據集。
CONCLUSIONS:Breath analysis for cancer screening and early detection shows promise, because samples can be collected easily, safely, and frequently. While gas chromatography-mass spectrometry is considered the gold standard for identifying specific VOCs, breath analysis has moved into analyzing patterns of VOCs using a variety of different multiple sensor techniques, such as eNoses and nanomaterials. Further development of VOCs for early cancer detection requires clinical trials with standardized breath sampling methods.
結論：呼吸分析在癌癥篩查和早期檢測中具有應用前景，因為可以方便、安全、頻繁地采集樣本。雖然氣相色譜-質譜法被認為是識別特定VOC的金標準，但呼吸分析已經開始使用各種不同的多傳感器技術(如Enose和納米材料)分析VOC的模式。為了進一步開發(fā)用于早期癌癥檢測的揮發(fā)性有機化合物，需要采用標準化呼吸取樣方法進行臨床試驗
Keywords:Exhaled breath, volatile organic compounds (VOCs), biomarkers, lung cancer, colorectal cancer, breast cancer
關鍵詞：呼氣、揮發(fā)性有機物(VOCs)、生物標志物、肺癌、結直腸癌、乳腺癌
