Feasibility and diagnostic accuracy of an electronic nose in children with asthma and cystic fibrosis
電子鼻診斷患者哮喘和囊性纖維化可行性和準確性研究
Michiel A G E Bannier, Kim D G van de Kant, Quirijn Jöbsis and Edward Dompeling
Published 8 May 2019 • © 2019 IOP Publishing Ltd
Journal of Breath Research, Volume 13, Number 3
Abstract
The measurement of volatile organic compounds (VOCs) in exhaled breath is a promising tool for diagnosing and monitoring various lung diseases in children. Gas chromatography mass spectrometry (GC-MS) analysis is a frequently used standard technique for VOCs analysis. However, as GC-MS is an expensive and time-consuming technique, hand-held devices or electronic noses have been developed. Recently, the Aeonose was introduced as an easy-to-use hand-held eNose capable of point-of-care testing. Although first results using this eNose in adults are promising, studies in children are lacking. We therefore performed a cross-sectional study in 55 children and adolescents ≥6 years of age (20 children with moderate to severe asthma, 13 children with CF, and 22 healthy controls). The feasibility of the Aeonose was high (>98% successful measurements). The diagnostic accuracy was high for discriminating asthma from CF (Area Under the Receiver Operating Characteristic Curve [AUC] 0.90 [95% Confidence Interval 0.78–1.00] sensitivity 89% [65%–98%], specificity 77% [46%–94%]), and for the distinction between CF and healthy controls (AUC 0.87 [0.74–1.00], sensitivity 85% [54%–97%], specificity 77% [54%–91%]). However, the diagnostic accuracy for the discrimination between asthma and healthy controls was modest (AUC 0.79 [0.63–0.94], sensitivity 74% [49%–90%], specificity 91% [69%–98%]). This is the first study to report test results of the Aeonose in children and adolescents ≥6 years. This eNose showed a high feasibility with modest to good diagnostic accuracies in asthma and CF. This study was registered at clinicaltrial.gov (NCT ).
呼出氣體中揮發性有機物(VOC)的測定是診斷和監測兒童各種肺部疾病的一種有前沿工具。氣相色譜-質譜(GC-MS)分析是VOC分析常用的標準技術。然而，由于GC-MS是一種昂貴且耗時的技術，所以已經開發出手持設備或電子鼻。近，Aeonose被介紹為一種易于使用的手持E-nose，能夠進行護理點測試。雖然在成人中實驗中使用的個結果是有希望的，但對兒童的研究卻缺乏。因此，我們對55名年齡≥6歲的兒童和青少年(20名中度至重度哮喘兒童、13名CF兒童和22名健康對照者)進行了橫斷面研究。Aeonose的可行性很高(>98%的成功測量)。對哮喘與CF(受試者操作特征曲線下面積[AUC]0.90[95%置信區間0.78-1.00]敏感度89%[65%-98%]、特異性77%[46%-94%])以及對CF與健康對照者的區分(AUC 0.87[0.74–1.00]，敏感性85%【54%–97%】，特異性77%【54%–91%】)。然而，哮喘與健康對照之間的鑒別診斷準確度不高(AUC 0.79[0.63–0.94]、敏感度74%[49%–90%]、特異性91%[69%–98%]。這是*報道6歲以上兒童和青少年Aeonose檢測結果的研究。本研究在clinicaltrial.gov(NCT )上進行了注冊。
