An electronic nose can sniff out idiopathic pulmonary fibrosis
Silvano Dragonieri, Donato Lacedonia, Incoronata Caccavo, Pierluigi Carratu, Giovanna Elisiana Carpagnano, Teresa Ranieri, Maria Pia Foschino Barbaro, Onofrio Resta
European Respiratory Journal 2019 54: PA1294; DOI: 10.1183/.congress-2019.PA1294
Abstract
Background:The current diagnostic work-up and monitoring of idiopathic pulmonary fibrosis (IPF) is often invasive, time consuming and expensive. Breath analysis by electronic nose technology has shown potential in the diagnosis of numerous respiratory diseases. In this pilot study, we investigated whether exhaled breath analysis by an electronic nose could discriminate between patients with and without IPF.
目前特發性肺纖維化(IPF)的診斷工作和監測往往是侵入性的、耗時的、昂貴的。利用電子鼻技術進行呼吸分析在許多呼吸系統疾病的診斷中顯示出潛力。在這項初步研究中，我們研究了電子鼻呼氣分析是否可以區分患有和不患有IPF的患者。
Methods:We enrolled 10 patients with well-characterized IPF (UIP and NSIP patterns), 10 individuals with COPD and 10 healthy controls. An electronic nose (Cyranose 320) was used to analyze exhaled breath samples. Raw data were processed by Principal component reduction and Canonical discriminant analysis.
我們收集了10例特征性IPF(UIP和NSIP模式)患者，10例COPD患者和10例健康對照者。用電子鼻(Cyranose 320)分析呼出氣樣本。對原始數據進行主成分歸約和典型判別分析。
Results: The electronic nose could adequay discriminate among breath profiles of IPF, COPD and healthy controls, with a Cross Validated Accuracy of 96.7% (p<0.01).
電子鼻能充分區分IPF、COPD和健康對照組的呼吸特征，交叉驗證準確率為96.7%(p<0.01)
Conclusions:The exhaled breath Volatile Organic Compounds- profile of patients with IPF can be detected by an electronic nose. This suggests that breath analysis has potential for diagnosis and/or monitoring of IPF.
IPF患者呼出氣中揮發性有機物可通過電子鼻進行檢測。這表明呼吸分析有可能診斷和/或監測IPF。
