女人被暴躁C到高潮容易怀孕吗_国产成人精品一区二区三区视频_国产欧美日韩_德国FREE性VIDEO极品

圖拉揚(yáng)科技
免費(fèi)會(huì)員
折光儀/折射儀
熔點(diǎn)測(cè)試儀
應(yīng)力儀
旋光儀
振蕩器、搖床
生物顯微鏡
分析天平
離子色譜儀
粉碎儀
X熒光光譜儀
微波消解儀/萃取儀
表面張力儀
酶標(biāo)儀
洗板機(jī)
固相萃取儀
動(dòng)物呼吸機(jī)/麻醉機(jī)
細(xì)胞破碎儀
細(xì)胞融合儀
混勻器
血壓,生物學(xué)功能
裂隙燈顯微鏡
超低溫冰箱
行為學(xué),條件作用,迷宮
動(dòng)物代謝,攝食行為
葉面積儀
植物光合儀
葉綠素儀
植物冠層分析儀
莖桿強(qiáng)度測(cè)定儀
葉片溫差儀
植物效率儀
輻射檢測(cè)儀
濁度儀
顆粒物分析儀
澄明度檢測(cè)儀
片劑厚度儀
凍力測(cè)試儀
勃氏粘度計(jì)
片劑多用測(cè)定儀
藥物融變時(shí)限儀
溶出度儀
明膠透明度測(cè)定儀
藥物透皮擴(kuò)散試驗(yàn)儀
熱源測(cè)溫儀
細(xì)菌內(nèi)毒素測(cè)定儀
微粒檢測(cè)儀
膏藥軟化點(diǎn)測(cè)定儀
氮吹儀
運(yùn)動(dòng)協(xié)調(diào),抓力測(cè)試,活動(dòng)性
顯微鏡載物臺(tái)
水果無(wú)損分析儀
粉質(zhì)分析儀
定氮儀
脂肪測(cè)定儀
消解儀
纖維測(cè)定儀
液相色譜儀
ATP熒光檢測(cè)儀
乳品分析儀
粉末性能測(cè)試儀
密度計(jì)/密度儀
農(nóng)藥殘留檢測(cè)儀
脆碎度測(cè)定儀
片劑硬度儀
霉菌毒素測(cè)定儀
消化爐
水分活度儀
獸藥殘留檢測(cè)儀
食品安全檢測(cè)儀
農(nóng)產(chǎn)品質(zhì)量安全檢測(cè)儀
色度計(jì)
厭氧工作站
磁力攪拌器
紫外可見(jiàn)分光光度計(jì)
分光光度計(jì)
色差儀
紅外水分測(cè)定儀
蠕動(dòng)泵
疼痛,炎癥
測(cè)汞儀
原子吸收光譜儀
電泳儀/電泳槽
凝膠成像系統(tǒng)
PCR儀
紫外分析儀
毛細(xì)管電泳
極譜儀/伏安儀
微量水分儀
旋轉(zhuǎn)蒸發(fā)儀
粘度計(jì)
真空泵
水浴/油浴/金屬浴
氣體檢漏儀
流變儀
微生物采樣器
激光粒度儀
氫氣發(fā)生器
氣相色譜儀
卡爾·費(fèi)休水分儀
崩解儀
滴定儀
PH酸度計(jì)
熒光分光光度計(jì)
紅外分光光度計(jì)
滅菌器/滅菌箱

測(cè)量呼出氣體揮發(fā)性有機(jī)化合物以檢測(cè)阿爾茨海默病和帕金森病

時(shí)間:2020/12/25閱讀:420
分享:
  Measuring Compounds in Exhaled Air to Detect Alzheimer's Disease and Parkinson’s Disease
 
  測(cè)量呼出氣體揮發(fā)性有機(jī)化合物以檢測(cè)阿爾茨海默病和帕金森病
 
  Jan-Philipp Bach , Maike Gold , David Mengel , Akira Hattesohl, Dirk Lubbe, Severin Schmid, Björn Tackenberg, Jürgen Rieke,
 
  Sasidhar Maddula, Jörg Ingo Baumbach, Christoph Nell, Tobias Boeselt, Joan Michelis, Judith Alferink, Michael Heneka, Wolfgang Oer,
 
  Frank Jessen, Sabina Janciauskiene, Claus Vogelmeier, Richard Dodel , Andreas Rembert Koczulla
 
  Abstract
 
  Background
 
  Alzheimer’s disease (AD) is diagnosed based upon medical history, neuropsychiatric examination, cerebrospinal fluid analysis, extensive laboratory analyses and cerebral imaging. Diagnosis is time consuming and labour intensive. Parkinson’s disease (PD) is mainly diagnosed on clinical grounds.
 
  阿爾茨海默病(AD)根據(jù)病史,神經(jīng)精神病學(xué)檢查,腦脊液分析,廣泛的實(shí)驗(yàn)室分析和腦成像診斷。診斷耗時(shí)且勞動(dòng)強(qiáng)度大。帕金森病(PD)主要是根據(jù)臨床原因診斷出來(lái)的。
 
  Objective
 
  The primary aim of this study was to differentiate patients suffering from AD, PD and healthy controls by investigating exhaled air with the electronic nose technique. After demonstrating a difference between the three groups the secondary aim was the identification of specific substances responsible for the difference(s) using ion mobility spectroscopy. Thirdly we analysed whether amyloid beta (Aβ) in exhaled breath was causative for the observed differences between patients suffering from AD and healthy controls.
 
  本研究的主要目的是通過(guò)電子鼻技術(shù)研究呼出氣,來(lái)區(qū)分患有AD,PD和健康對(duì)照的患者。在證明三組之間的差異之后,次要目標(biāo)是使用離子遷移譜來(lái)鑒定造成差異的特定物質(zhì)。第三,我們分析呼出氣中的β淀粉樣蛋白(Aβ)是否是導(dǎo)致患有AD和健康對(duì)照的患者之間觀察到的差異的原因。
 
  Methods
 
  We employed novel pulmonary diagnostic tools (electronic nose device/ion-mobility spectrometry) for the identification of patients with neurodegenerative diseases. Specifically, we analysed breath pattern differences in exhaled air of patients with AD, those with PD and healthy controls using the electronic nose device (eNose). Using ion mobility spectrometry (IMS), we identified the compounds responsible for the observed differences in breath patterns. We applied ELISA technique to measure Aβ in exhaled breath condensates.
 
  我們采用新型肺部診斷工具(電子鼻/離子遷移譜儀)來(lái)識(shí)別神經(jīng)退行性疾病患者。具體而言,我們使用電子鼻裝置(eNose)分析了患有AD的患者,具有PD的患者和健康對(duì)照的呼出氣體中的呼吸模式差異。使用離子遷移譜(IMS),我們確定了導(dǎo)致觀察到的呼吸模式差異的化合物。我們應(yīng)用ELISA技術(shù)測(cè)量呼出氣冷凝物中的Aβ。
 
  Results
 
  The eNose was able to differentiate between AD, PD and HC correctly. Using IMS, we identified markers that could be used to differentiate healthy controls from patients with AD and PD with an accuracy of 94%. In addition, patients suffering from PD were identified with sensitivity and specificity of 100%. Altogether, 3 AD patients out of 53 participants were misclassified. Although we found Aβ in exhaled breath condensate from both AD and healthy controls, no significant differences between groups were detected.
 
  eNose能夠正確區(qū)分AD,PD和HC。使用IMS,我們確定了可用于區(qū)分健康對(duì)照與AD和PD患者的標(biāo)記物,準(zhǔn)確度為94%。此外,患有PD的患者被鑒定為具有100%的敏感性和特異性。總共有53名參與者中的3名AD患者被錯(cuò)誤分類。雖然我們發(fā)現(xiàn)來(lái)自AD和健康對(duì)照的呼出氣冷凝物中的Aβ,但未檢測(cè)到組之間的顯著差異。
 
  Conclusion
 
  These data may open a new field in the diagnosis of neurodegenerative disease such as Alzheimer’s disease and Parkinson’s disease. Further research is required to evaluate the significance of these pulmonary findings with respect to the pathophysiology of neurodegenerative disorders.
 
  這些數(shù)據(jù)可能為神經(jīng)退行性疾病如阿爾茨海默病和帕金森病的診斷開(kāi)辟了新的領(lǐng)域。需要進(jìn)一步的研究來(lái)評(píng)估這些肺部發(fā)現(xiàn)對(duì)于神經(jīng)退行性疾病的病理生理學(xué)的重要性。

會(huì)員登錄

×

請(qǐng)輸入賬號(hào)

請(qǐng)輸入密碼

=

請(qǐng)輸驗(yàn)證碼

收藏該商鋪

X
該信息已收藏!
標(biāo)簽:
保存成功

(空格分隔,最多3個(gè),單個(gè)標(biāo)簽最多10個(gè)字符)

常用:

提示

X
您的留言已提交成功!我們將在第一時(shí)間回復(fù)您~
在線留言